The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part I
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
CD4+ effector cells, based on cytokine production, nuclear receptors and signaling pathways, have been categorized into four subsets.
T-helper-1 cells produce IFN-γ, TNF-β, lymphotoxin and IL-10; T-helper-2 cells produce IL-4, IL-5, IL-10, IL-13, IL-21 and IL-31; T-helper-3, or regulatory T-cells, produce IL-10, TGF-β and IL-35; and the recently discovered T-helper-17 cell produces IL-17, IL-17A, IL-17F, IL-21, IL-26 and CCL20.
By producing IL-17 and other signaling molecules, Th17 contributes to the pathogenesis of multiple autoimmune diseases including allergic inflammation, rheumatoid arthritis, autoimmune gastritis, inflammatory bowel disease, psoriasis and multiple sclerosis.
In this article, we review the differential regulation of inflammation in different tissues with a major emphasis on enhancement of neuroinflammation by local production of IL-17 in the brain.
By understanding the role of pathogenic factors in the induction of autoimmune diseases by Th17 cells, CAM practitioners will be able to design CAM therapies targeting Th17 and associated cytokine activities and signaling pathways to repair the intestinal and blood-brain barriers for their patients with autoimmunities, in particular, those with neuroinflammation and neurodegeneration.
American Psychological Association (APA)
Vojdani, Aristo& Lambert, Jama. 2011. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part I. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508762
Modern Language Association (MLA)
Vojdani, Aristo& Lambert, Jama. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part I. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-508762
American Medical Association (AMA)
Vojdani, Aristo& Lambert, Jama. The Role of Th17 in Neuroimmune Disorders : Target for CAM Therapy. Part I. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508762
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508762