Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence
Joint Authors
Karakitsos, Petros
Meristoudis, Christos
Spathis, Aris
Aga, Evaggelia
Alepaki, Maria
Chranioti, Aikaterini
Panayiotides, Ioannis
Kassanos, Dimitrios
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cervical cancer is a common cancer inflicting women worldwide.
Even though, persistent infection with oncogenic Human Papillomavirus (HPV) types is considered the most important risk factor for cervical cancer development, less than 5% of women with HPV will eventually develop cervical cancer supporting that other molecular events, like methylation-dependent inactivation of tumor suppressor genes, may cocontribute in cervical carcinogenesis.
We analyzed promoter methylation of three candidate genes (p16, MGMT, and hMLH1) in 403 liquid-based cytology samples.
Methylation was commonly identified in both benign and pathologic samples and correlated with higher lesion grade determined by cytological, colposcopical, or histological findings, with HPV DNA and mRNA positivity of specific HPV types and p16INK4A protein expression.
Overall accuracy of methylation is much lower than traditional diagnostic tests ranking it as an ancillary technique with more data needed to identify the exact value of methylation status in cervical carcinogenesis.
American Psychological Association (APA)
Spathis, Aris& Aga, Evaggelia& Alepaki, Maria& Chranioti, Aikaterini& Meristoudis, Christos& Panayiotides, Ioannis…[et al.]. 2011. Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-508822
Modern Language Association (MLA)
Spathis, Aris…[et al.]. Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-508822
American Medical Association (AMA)
Spathis, Aris& Aga, Evaggelia& Alepaki, Maria& Chranioti, Aikaterini& Meristoudis, Christos& Panayiotides, Ioannis…[et al.]. Promoter Methylation of p16INK4A, hMLH1, and MGMT in Liquid-Based Cervical Cytology Samples Compared with Clinicopathological Findings and HPV Presence. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-508822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508822