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The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cellular inhibitors of apoptosis proteins 1 and 2 (cIAP1/2) are members of the inhibitor of apoptosis protein (IAP) family that has been implicated in the pathology of human cancers due to their overexpression and function as blockers of cell death in various cancers.
As a result, small molecule IAP antagonists have been developed and are currently under clinical evaluation for potential therapeutic use.
In contrast, recent evidence has indicated a tumour-suppressing role for the cIAPs.
Mutations in or loss of cIAPs have been identified as molecular lesions that contribute to constitutive activation of NF-κB in hematopoietic malignancies.
These studies reveal a context-dependent role for the cIAPs wherein both their overexpression and loss may contribute to tumourigenesis.
American Psychological Association (APA)
Lau, R.& Pratt, M. A. C.. 2012. The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-508856
Modern Language Association (MLA)
Lau, R.& Pratt, M. A. C.. The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer. ISRN Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-508856
American Medical Association (AMA)
Lau, R.& Pratt, M. A. C.. The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-508856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508856