The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation
Joint Authors
Lim, Soon Sung
Cui, Cheng Bi
Jang, Jai Man
Kwon, Sang Oh
Li, Hong Mei
Kim, Jin Kyu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To evaluate the aldose reductase (AR) enzyme inhibitory ability of Prunella vulgaris L.
extract, six compounds were isolated and tested for their effects.
The components were subjected to in vitro bioassays to investigate their inhibitory assays using rat lens aldose reductase (rAR) and human recombinant AR (rhAR).
Among them, caffeic acid ethylene ester showed the potent inhibition, with the IC50 values of rAR and rhAR at 3.2±0.55 μM and 12.58±0.32 μM, respectively.
In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/concentration of substrate, this compound showed noncompetitive inhibition against rhAR.
Furthermore, it inhibited galactitol formation in a rat lens incubated with a high concentration of galactose.
Also it has antioxidative as well as advanced glycation end products (AGEs) inhibitory effects.
As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.
American Psychological Association (APA)
Li, Hong Mei& Kim, Jin Kyu& Jang, Jai Man& Kwon, Sang Oh& Cui, Cheng Bi& Lim, Soon Sung. 2012. The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508863
Modern Language Association (MLA)
Li, Hong Mei…[et al.]. The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508863
American Medical Association (AMA)
Li, Hong Mei& Kim, Jin Kyu& Jang, Jai Man& Kwon, Sang Oh& Cui, Cheng Bi& Lim, Soon Sung. The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508863