Autoregulation of the Brain Temperature during Whole Body Hyperthermia

Abstract EN

The aim of this study was revealing the temperature changes in rats' brain tissue caused by whole body hyperthermia.

The analysis of received results allows to conclude that the brain has a highly secured system of temperature autoregulation against the exogenous temperature changes.

The upper limit of this autoregulation (for rats, at least) is in the range of 45°C of environment.

An important role in the normal functioning of the brain temperature autoregulation system belongs to Nitric Oxide.

The behavioral disorders, observed in animals after whole body hyperthermia (sure within the range of brain temperature autoregulation) are hardly associated with the changes in temperature of the Central Nervous System, but rather have to be mediated by impaired blood circulation and oxygen supply to the brain tissues, caused by the rapid deterioration of the blood rheological properties.