Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1
Joint Authors
Chudek, Jerzy
Więcek, Andrzej
Piecha, Grzegorz
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary hyperparathyroidism may occur as a part of an inherited syndrome in a combination with pancreatic endocrine tumours and/or pituitary adenoma, which is classified as Multiple Endocrine Neoplasia type 1 (MEN-1).
This syndrome is caused by a germline mutation in MEN-1 gene encoding a tumour-suppressor protein, menin.
Primary hyperparathyroidism is the most frequent clinical presentation of MEN-1, which usually appears in the second decade of life as an asymptomatic hypercalcemia and progresses through the next decades.
The most frequent clinical presentation of MEN-1-associated primary hyperparathyroidism is bone demineralisation and recurrent kidney stones rarely followed by chronic kidney disease.
The aim of this paper is to present the pathomechanism, screening procedures, diagnosis, and management of primary hyperparathyroidism in the MEN-1 syndrome.
It also summarises the recent advances in the pharmacological therapy with a new group of drugs—calcimimetics.
American Psychological Association (APA)
Piecha, Grzegorz& Chudek, Jerzy& Więcek, Andrzej. 2011. Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-508885
Modern Language Association (MLA)
Piecha, Grzegorz…[et al.]. Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1. International Journal of Endocrinology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-508885
American Medical Association (AMA)
Piecha, Grzegorz& Chudek, Jerzy& Więcek, Andrzej. Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1. International Journal of Endocrinology. 2011. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-508885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508885