A Bayesian Model Averaging Approach to the Quantification of Overlapping Peptides in an MALDI-TOF Mass Spectrum
Joint Authors
Burzykowski, Tomasz
Zhu, Qi
Valkenborg, Dirk
Kasim, Adetayo
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In a high-resolution MALDI-TOF mass spectrum, a peptide produces multiple peaks, corresponding to the isotopic variants of the molecules.
An overlap occurs when two peptides appear in the vicinity of the mass coordinate, resulting in the difficulty of quantifying the relative abundance and the exact masses of these peptides.
To address the problem, two factors need to be considered: (1) the variability pertaining to the abundances of the isotopic variants (2) extra information content needed to supplement the information contained in data.
We propose a Bayesian model for the incorporation of prior information.
Such information exists, for example, for the distribution of the masses of peptides and the abundances of the isotopic variants.
The model we develop allows for the correct estimation of the parameters of interest.
The validity of the modeling approach is verified by a real-life case study from a controlled mass spectrometry experiment and by a simulation study.
American Psychological Association (APA)
Zhu, Qi& Kasim, Adetayo& Valkenborg, Dirk& Burzykowski, Tomasz. 2011. A Bayesian Model Averaging Approach to the Quantification of Overlapping Peptides in an MALDI-TOF Mass Spectrum. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-508887
Modern Language Association (MLA)
Zhu, Qi…[et al.]. A Bayesian Model Averaging Approach to the Quantification of Overlapping Peptides in an MALDI-TOF Mass Spectrum. International Journal of Proteomics No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-508887
American Medical Association (AMA)
Zhu, Qi& Kasim, Adetayo& Valkenborg, Dirk& Burzykowski, Tomasz. A Bayesian Model Averaging Approach to the Quantification of Overlapping Peptides in an MALDI-TOF Mass Spectrum. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-508887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508887