Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population
Joint Authors
Liu, Xiufang
Zheng, Bixia
Cai, Zhenming
Guo, Wenwen
Sun, Wei
Wang, Ya-Ping
Chen, Huimei
Tao, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The base excision repair (BER) pathway, containing OGG1, MTH1 and MUTYH, is a major protector from oxidative DNA damage in humans, while 8-oxoguanine (8-OHdG), an index of DNA oxidation, is increased in maintenance hemodialysis (HD) patients.
Four polymorphisms of BER genes, OGG1 c.977C > G (rs1052133), MTH1 c.247G > A (rs4866), MUTYH c.972G > C (rs3219489), and AluYb8MUTYH (rs10527342), were examined in 337 HD patients and 404 healthy controls.
And the 8-OHdG levels in leukocyte DNA were examined in 116 HD patients.
The distribution of MUTYH c.972 GG or AluYb8MUTYH differed between the two groups and was associated with a moderately increased risk for end-stage renal disease (ESRD) (P=0.013 and 0.034, resp.).
The average 8-OHdG/106 dG value was significantly higher in patients with the OGG1 c.977G, MUTYH c.972G or AluYb8MUTYH alleles (P<0.001 via ANOVA).
Further analysis showed that combination of MUTYH c.972GG with OGG1 c.977GG or AluYb8MUTYH increased both the risk for ESRD and leukocyte DNA 8-OHdG levels in HD patients.
Our study showed that MUTYH c.972GG, AluYb8MUTYH, and combination of OGG1 c.977GG increased the risk for ESRD development in China and suggested that DNA oxidative damage might be involved in such process.
American Psychological Association (APA)
Cai, Zhenming& Chen, Huimei& Tao, Jing& Guo, Wenwen& Liu, Xiufang& Zheng, Bixia…[et al.]. 2012. Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-508891
Modern Language Association (MLA)
Cai, Zhenming…[et al.]. Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-508891
American Medical Association (AMA)
Cai, Zhenming& Chen, Huimei& Tao, Jing& Guo, Wenwen& Liu, Xiufang& Zheng, Bixia…[et al.]. Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-508891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508891