Sarcoidosis : Immunopathogenesis and Immunological Markers
Joint Authors
Herbert, Cristan
Loke, Wei Sheng Joshua
Thomas, Paul S.
Source
International Journal of Chronic Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sarcoidosis is a multisystem granulomatous disorder invariably affecting the lungs.
It is a disease with noteworthy variations in clinical manifestation and disease outcome and has been described as an “immune paradox” with peripheral anergy despite exaggerated inflammation at disease sites.
Despite extensive research, sarcoidosis remains a disease with undetermined aetiology.
Current evidence supports the notion that the immune response in sarcoidosis is driven by a putative antigen in a genetically susceptible individual.
Unfortunately, there currently exists no reliable biomarker to delineate the disease severity and prognosis.
As such, the diagnosis of sarcoidosis remains a vexing clinical challenge.
In this review, we outline the immunological features of sarcoidosis, discuss the evidence for and against various candidate etiological agents (infective and noninfective), describe the exhaled breath condensate, a novel method of identifying immunological biomarkers, and suggest other possible immunological biomarkers to better characterise the immunopathogenesis of sarcoidosis.
American Psychological Association (APA)
Loke, Wei Sheng Joshua& Herbert, Cristan& Thomas, Paul S.. 2013. Sarcoidosis : Immunopathogenesis and Immunological Markers. International Journal of Chronic Diseases،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-508907
Modern Language Association (MLA)
Loke, Wei Sheng Joshua…[et al.]. Sarcoidosis : Immunopathogenesis and Immunological Markers. International Journal of Chronic Diseases No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-508907
American Medical Association (AMA)
Loke, Wei Sheng Joshua& Herbert, Cristan& Thomas, Paul S.. Sarcoidosis : Immunopathogenesis and Immunological Markers. International Journal of Chronic Diseases. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-508907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508907