Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides
Joint Authors
Kishore, Raj
Yaar, Mina
Sasi, Sharath P.
Qin, Gangjian
Coleman, Christina
Levine, Danielle
Lambers, Erin
Gilchrest, Barbara A.
Goukassian, David A.
Thorne, Tina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Telomere homolog oligonucleotides (T-oligos) activate an innate telomere-based program that leads to multiple anticancer effects.
T-oligos act at telomeres to initiate signaling through the Werner protein and ATM kinase.
We wanted to determine if T-oligos have antiangiogenic effects.
We found that T-oligo-treated human melanoma (MM-AN) cells had decreased expression of vascular endothelial growth factor (VEGF), VEGF receptor 2, angiopoeitin-1 and -2 and decreased VEGF secretion.
T-oligos activated the transcription factor E2F1 and inhibited the activity of the angiogenic transcription factor, HIF-1α.
T-oligos inhibited EC tubulogenesis and total tumor microvascular density matrix invasion by MM-AN cells and ECs in vitro.
In melanoma SCID xenografts, two systemic T-oligo injections decreased by 60% (P<.004) total tumor microvascular density and the functional vessels density by 80% (P<.002).
These findings suggest that restriction of tumor angiogenesis is among the host's innate telomere-based anticancer responses and provide further evidence that T-oligos may offer a powerful new approach for melanoma treatment.
American Psychological Association (APA)
Coleman, Christina& Levine, Danielle& Kishore, Raj& Qin, Gangjian& Thorne, Tina& Lambers, Erin…[et al.]. 2010. Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. Journal of Oncology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-508912
Modern Language Association (MLA)
Coleman, Christina…[et al.]. Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. Journal of Oncology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-508912
American Medical Association (AMA)
Coleman, Christina& Levine, Danielle& Kishore, Raj& Qin, Gangjian& Thorne, Tina& Lambers, Erin…[et al.]. Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-508912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508912