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Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives
Joint Authors
Hasan Rama, Nasim
Iqbal, Jamshed
Saleem, Muhammad
Hanif, Muhammad
Shoaib, Khurram
Zaib, Sumera
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles.
Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol.
The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease.
The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds.
The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.
American Psychological Association (APA)
Hanif, Muhammad& Shoaib, Khurram& Saleem, Muhammad& Hasan Rama, Nasim& Zaib, Sumera& Iqbal, Jamshed. 2012. Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508929
Modern Language Association (MLA)
Hanif, Muhammad…[et al.]. Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives. ISRN Pharmacology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-508929
American Medical Association (AMA)
Hanif, Muhammad& Shoaib, Khurram& Saleem, Muhammad& Hasan Rama, Nasim& Zaib, Sumera& Iqbal, Jamshed. Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508929