The Biological and Metabolic Fates of Endogenous DNA Damage Products
Joint Authors
Dedon, Peter C.
Chan, Simon Wan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
DNA and other biomolecules are subjected to damaging chemical reactions during normal physiological processes and in states of pathophysiology caused by endogenous and exogenous mechanisms.
In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that reflect the local chemical pathology such as oxidative stress and inflammation.
These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways.
Toward the goal of developing biomarkers, significant effort has been made to detect and quantify damage biomolecules in clinically accessible compartments such as blood and and urine.
However, there has been little effort to define the biotransformational fate of damaged biomolecules as they move from the site of formation to excretion in clinically accessible compartments.
This paper highlights examples of this important problem with DNA damage products.
American Psychological Association (APA)
Chan, Simon Wan& Dedon, Peter C.. 2010. The Biological and Metabolic Fates of Endogenous DNA Damage Products. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-508948
Modern Language Association (MLA)
Chan, Simon Wan& Dedon, Peter C.. The Biological and Metabolic Fates of Endogenous DNA Damage Products. Journal of Nucleic Acids No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-508948
American Medical Association (AMA)
Chan, Simon Wan& Dedon, Peter C.. The Biological and Metabolic Fates of Endogenous DNA Damage Products. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-508948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508948