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Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats
Joint Authors
Afolayan, Anthony Jide
Sunmonu, Taofik O.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Artemisia afra Jacq.
ex Willd.
is a widely used medicinal plant in South Africa for the treatment of diabetes.
This study aimed to evaluate the hypoglycemic activity and possible toxicity effect of aqueous leaf extract of the herb administered at different dosages for 15 days in streptozotocin-induced diabetic rats.
Administration of the extract at 50, 100, and 200 mg/kg body weight significantly (P<0.05) increased body weight, decreased blood glucose levels, increased glucose tolerance, and improved imbalance in lipid metabolism in diabetic rats.
These are indications of antidiabetic property of A.
afra with 200 mg/kg body weight of the extract showing the best hypoglycemic action by comparing favourably well with glibenclamide, a standard hypoglycemic drug.
The extract at all dosages tested also restored liver function indices and haematological parameters to normal control levels in the diabetic rats, whereas the kidney function indices were only normalized in the diabetic animals administered with 50 mg/kg body weight of the extract.
This investigation clearly showed that in addition to its hypoglycemic activity, A.
afra may also protect the liver and blood against impairment due to diabetes.
However, some kidney functions may be compromised at high dosages of the extract.
American Psychological Association (APA)
Sunmonu, Taofik O.& Afolayan, Anthony Jide. 2013. Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508952
Modern Language Association (MLA)
Sunmonu, Taofik O.& Afolayan, Anthony Jide. Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508952
American Medical Association (AMA)
Sunmonu, Taofik O.& Afolayan, Anthony Jide. Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508952