The Hypoxic Testicle : Physiology and Pathophysiology
Joint Authors
Parraga, Mario
Henríquez-Olavarrieta, Sebastián
Farias, Jorge G.
Zepeda, Andrea B.
Madrid, Eva
Moreno, Ricardo D.
Reyes, Juan G.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mammalian spermatogenesis is a complex biological process occurring in the seminiferous tubules in the testis.
This process represents a delicate balance between cell proliferation, differentiation, and apoptosis.
In most mammals, the testicles are kept in the scrotum 2 to 7°C below body core temperature, and the spermatogenic process proceeds with a blood and oxygen supply that is fairly independent of changes in other vascular beds in the body.
Despite this apparently well-controlled local environment, pathologies such as varicocele or testicular torsion and environmental exposure to low oxygen (hypoxia) can result in changes in blood flow, nutrients, and oxygen supply along with an increased local temperature that may induce adverse effects on Leydig cell function and spermatogenesis.
These conditions may lead to male subfertility or infertility.
Our literature analyses and our own results suggest that conditions such as germ cell apoptosis and DNA damage are common features in hypoxia and varicocele and testicular torsion.
Furthermore, oxidative damage seems to be present in these conditions during the initiation stages of germ cell damage and apoptosis.
Other mechanisms like membrane-bound metalloproteinases and phospholipase A2 activation could also be part of the pathophysiological consequences of testicular hypoxia.
American Psychological Association (APA)
Reyes, Juan G.& Farias, Jorge G.& Henríquez-Olavarrieta, Sebastián& Madrid, Eva& Parraga, Mario& Zepeda, Andrea B.…[et al.]. 2012. The Hypoxic Testicle : Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-508972
Modern Language Association (MLA)
Reyes, Juan G.…[et al.]. The Hypoxic Testicle : Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-508972
American Medical Association (AMA)
Reyes, Juan G.& Farias, Jorge G.& Henríquez-Olavarrieta, Sebastián& Madrid, Eva& Parraga, Mario& Zepeda, Andrea B.…[et al.]. The Hypoxic Testicle : Physiology and Pathophysiology. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-508972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508972