Alzheimer's Disease and Vascular Deficiency : Lessons from Imaging Studies and Down Syndrome
Joint Authors
Petersen, Robert B.
Zhu, Xiongwei
Lee, Hyoung-gon
Reed, Charles
Perry, George
Reed-Cossairt, Arlene
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Down syndrome (DS) individuals are at high risk for developing Alzheimer's disease (AD) and consequently provide a unique opportunity to examine the factors leading to the onset of AD.
This paper focuses on the neglected vascular parallels between AD and DS that can readily be examined in DS.
Several recent AD studies provide evidence that internal jugular vein (IJV) reflux may result in white matter lesions and a 30% decrease in cerebrospinal fluid (CSF) clearance of amyloid-β.
At the same time, studies analyzing the synthesis of amyloid-β in DS showed greater than expected amounts of Aβ than would be predicted by the increase in gene dosage, perhaps due to slower clearance.
These studies are discussed along with the possibility that the venous and CSF dysfunction found in AD patients may be present early in life in persons with DS, leaving them particularly vulnerable to early onset AD.
Studying IJV function in DS provides an opportunity to understand the role of vascular function in the initiation of AD.
American Psychological Association (APA)
Reed-Cossairt, Arlene& Zhu, Xiongwei& Lee, Hyoung-gon& Reed, Charles& Perry, George& Petersen, Robert B.. 2012. Alzheimer's Disease and Vascular Deficiency : Lessons from Imaging Studies and Down Syndrome. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509009
Modern Language Association (MLA)
Reed-Cossairt, Arlene…[et al.]. Alzheimer's Disease and Vascular Deficiency : Lessons from Imaging Studies and Down Syndrome. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-509009
American Medical Association (AMA)
Reed-Cossairt, Arlene& Zhu, Xiongwei& Lee, Hyoung-gon& Reed, Charles& Perry, George& Petersen, Robert B.. Alzheimer's Disease and Vascular Deficiency : Lessons from Imaging Studies and Down Syndrome. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509009