HBX-Mediated Migration of HBV-Replicating HepG2 Cells : Insights on Development of Hepatocellular Carcinoma
Joint Authors
Feng, Huixing
Li, Xi
Zhang, Jianhua
Chen, Wei Ning
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hepatitus B virus (HBV) is a major cause of the development of hepatpcellular carcinoma (HCC).
One of the significant characteristics of tumor progression is cell migration which is reflective of cytoskeletal dynamics.
The Rho GTPases contribute to a multiple cellular processes, including the cellular cytoskeletal reorganization and motility.
It has been found that some Rho GTPases have oncogenic activity and can promote cancer cell invasion.
Here we discuss one of the Rho GTPases, Rac1 can be activated by HBV replication and such activation results in the high motility of HBV-replicating cells.
The enhanced cell motility can be interestingly alleviated by the mutation at the sites of proline rich domain located in HBX.
Our findings may provide new insights on the mechanism of HCC development associated with chronic HBV infection.
American Psychological Association (APA)
Feng, Huixing& Zhang, Jianhua& Li, Xi& Chen, Wei Ning. 2009. HBX-Mediated Migration of HBV-Replicating HepG2 Cells : Insights on Development of Hepatocellular Carcinoma. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-509042
Modern Language Association (MLA)
Feng, Huixing…[et al.]. HBX-Mediated Migration of HBV-Replicating HepG2 Cells : Insights on Development of Hepatocellular Carcinoma. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-509042
American Medical Association (AMA)
Feng, Huixing& Zhang, Jianhua& Li, Xi& Chen, Wei Ning. HBX-Mediated Migration of HBV-Replicating HepG2 Cells : Insights on Development of Hepatocellular Carcinoma. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-509042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509042