Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics : Potential 5-HT2A Antagonist
Joint Authors
Kokil, Ganesh Rajendra
Harak, Shilpa Sudhakar
Jadhav, Mahantesh Namdev
Wagh, Sanjay Baburao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness.
Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile.
Development of novel hybrid atypical tricyclic antipsychotic pharmacophore was achieved using direct (by measuring docking score of designed molecules on modelled 5-HT2A receptor) and indirect (current, clinically available therapeutic agents’ data) drug design approaches.
American Psychological Association (APA)
Jadhav, Mahantesh Namdev& Kokil, Ganesh Rajendra& Harak, Shilpa Sudhakar& Wagh, Sanjay Baburao. 2013. Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics : Potential 5-HT2A Antagonist. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509054
Modern Language Association (MLA)
Jadhav, Mahantesh Namdev…[et al.]. Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics : Potential 5-HT2A Antagonist. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-509054
American Medical Association (AMA)
Jadhav, Mahantesh Namdev& Kokil, Ganesh Rajendra& Harak, Shilpa Sudhakar& Wagh, Sanjay Baburao. Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics : Potential 5-HT2A Antagonist. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509054