Exploring the Nature of Desmosomal Cadherin Associations in 3D
Joint Authors
Owen, Gethin R.
Stokes, David L.
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Desmosomes are a complex assembly of protein molecules that mediate adhesion between adjacent cells.
Desmosome composition is well established and spatial relationships between components have been identified.
Intercellular cell-cell adhesion is created by the interaction of extracellular domains of desmosomal cadherins, namely, desmocollins and desmogleins.
High-resolution methods have provided insight into the structural interactions between cadherins.
However, there is a lack of understanding about the architecture of the intact desmosomes and the physical principles behind their adhesive strength are unclear.
Electron Tomography (ET) studies have offered three-dimensional visual data of desmosomal cadherin associations at molecular resolution.
This review discusses the merits of two cadherin association models represented using ET.
We discuss the possible role of sample preparation on the structural differences seen between models and the possibility of adaptive changes in the structure as a direct consequence of mechanical stress and stratification.
American Psychological Association (APA)
Owen, Gethin R.& Stokes, David L.. 2010. Exploring the Nature of Desmosomal Cadherin Associations in 3D. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-509063
Modern Language Association (MLA)
Owen, Gethin R.& Stokes, David L.. Exploring the Nature of Desmosomal Cadherin Associations in 3D. Dermatology Research and Practice No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-509063
American Medical Association (AMA)
Owen, Gethin R.& Stokes, David L.. Exploring the Nature of Desmosomal Cadherin Associations in 3D. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-509063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509063