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Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma)
Joint Authors
Meduri, Francesco
Fadini, Gian Paolo
Lanza, Cristiano
Avogaro, Angelo
Pelizzo, Mariarosa
Maran, Alberto
Altavilla, Giuseppe
Miotto, Diego
Valerio, Anna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We describe an unusual case of hypoglycemic syndrome in a 69-year old woman with a proinsulin-only secreting pancreatic endocrine adenoma.
The clinical history was highly suggestive of an organic hypoglycemia, with normal or relatively low insulin concentrations and elevated proinsulin levels.
Magnetic resonance and computed tomography of the abdomen showed a 1 cm pancreatic nodule and multiple accessory spleens.
The diagnosis was confirmed by selective angiography, showing location and vascularization of the nodule, despite no response to intra-arterial calcium.
After resection, the hypoglycemic syndrome resolved.
The surgical specimen was comprised of a neuroendocrine adenomatous tissue with high proinsulin immunoreactivity.
Study of this unusual case of proinsulinoma underlines (i) the need to assay proinsulin in patients with hypoglycemia and normal immunoreactive insulin, (ii) the differential diagnosis in the presence of accessory spleens, (iii) the unresponsiveness to intra-arterial calcium stimulation, and (iv) the extensive evaluation needed to reach a final diagnosis.
American Psychological Association (APA)
Fadini, Gian Paolo& Maran, Alberto& Valerio, Anna& Meduri, Francesco& Pelizzo, Mariarosa& Miotto, Diego…[et al.]. 2011. Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma). Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509111
Modern Language Association (MLA)
Fadini, Gian Paolo…[et al.]. Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma). Case Reports in Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-509111
American Medical Association (AMA)
Fadini, Gian Paolo& Maran, Alberto& Valerio, Anna& Meduri, Francesco& Pelizzo, Mariarosa& Miotto, Diego…[et al.]. Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma). Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509111