Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth
Joint Authors
Yu, Shi
Diao, Shu
Yang, Dongmei
Ding, Gang
Fan, Zhipeng
Wang, Jinsong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Stem cells isolated from exfoliated deciduous teeth (SHEDs) are highly capable of proliferation and differentiation, and they represent good cell sources for mesenchymal stem cell- (MSC-) mediated dental tissue regeneration, but the supply of SHEDs is limited.
A previous study found that stem cells could be isolated from inflamed tissues, but it is unknown whether primary dental pulp diagnosed with irreversible pulpitis might contain stem cells with appropriate tissue regeneration capacity.
In this study, we aimed to isolate stem cells from both inflamed pulps of deciduous teeth (SCIDs) and SHEDs from Chinese children and to compare their proliferation and differentiation potentials.
Our results showed that SCIDs were positive for cell surface markers, including CD105, CD90, and CD146, and they had high proliferation ability and osteogenic, adipogenic, and chondrogenic differentiation potentials.
There was no significant difference in proliferation and differentiation potentials between SCIDs and SHEDs.
The mRNA of inflammatory factors, including IL-1β, IL-6, and TNF-α, was expressed at similar levels in SCIDs and SHEDs, but SCIDs secreted more TNF-α protein.
In conclusion, our in vitro results showed that SCIDs have proliferation and differentiation potentials similar to those of SHEDs.
Thus, SCIDs represent a new potentially applicable source for MSC mediated tissue regeneration.
American Psychological Association (APA)
Yu, Shi& Diao, Shu& Wang, Jinsong& Ding, Gang& Yang, Dongmei& Fan, Zhipeng. 2014. Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-509112
Modern Language Association (MLA)
Yu, Shi…[et al.]. Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-509112
American Medical Association (AMA)
Yu, Shi& Diao, Shu& Wang, Jinsong& Ding, Gang& Yang, Dongmei& Fan, Zhipeng. Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-509112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509112