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Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment
Joint Authors
Sulaiman, Siti Amrah
Erejuwa, Omotayo O.
Ab Wahab, Mohd S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cancer cells generate reactive oxygen species (ROS) resulting from mitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities.
Available evidence also suggests that cancer cells depend on intrinsic ROS level for proliferation and survival.
Both physiological and pathophysiological roles have been ascribed to ROS which cause lipid peroxidation.
In spite of their injurious effects, the ROS and the resulting lipid peroxidation products could be beneficial in cancer treatment.
This review presents research findings suggesting that ROS and the resulting lipid peroxidation products could be utilized to inhibit cancer growth or induce cancer cell death.
It also underscores the potential of lipid peroxidation products to potentiate the antitumor effect of other anticancer agents.
The review also highlights evidence demonstrating other potential applications of lipid peroxidation products in cancer treatment.
These include the prospect of lipid peroxidation products as a diagnostic tool to predict the chances of cancer recurrence, to monitor treatment progress or how well cancer patients respond to therapy.
Further and detailed research is required on how best to successfully, effectively, and selectively target cancer cells in humans using lipid peroxidation products.
This may prove to be an important strategy to complement current treatment regimens for cancer patients.
American Psychological Association (APA)
Erejuwa, Omotayo O.& Sulaiman, Siti Amrah& Ab Wahab, Mohd S.. 2013. Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509138
Modern Language Association (MLA)
Erejuwa, Omotayo O.…[et al.]. Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-509138
American Medical Association (AMA)
Erejuwa, Omotayo O.& Sulaiman, Siti Amrah& Ab Wahab, Mohd S.. Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509138