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The Role of p53 and MDM2 in Head and Neck Cancer
Joint Authors
Adamo, V.
Lo Nigro, C.
Natoli, G.
Russi, Elvio Grazioso
Merlano, M. C.
Denaro, N.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Head and neck cancer is a complex disorder that includes mostly squamous cell carcinomas that can develop in the throat, larynx, nose, sinuses, and mouth.
Etiopathogenesis is due to tobacco and alcohol consumption and to infection by human papillomavirus (HPV) type 16/18.
Tumors often develop within preneoplastic fields of genetically altered cells.
Most head and neck cancers result from multistep accumulation of genetic alterationsm resulting in clonal outgrowth of transformed cells.
These DNA changes are caused by a variety of mechanisms like endogenous mutations and exogenous mutations.
Dysregulated molecular pathway includes alterations of critical inhibitor of cyclin CDK complexes, inactivating mutations of p53 gene, and activation of oncogenes and growth factors.
This paper attempts to review the role of p53 and MDM2 genetic aberrations and pathways in head and neck cancer.
American Psychological Association (APA)
Denaro, N.& Lo Nigro, C.& Natoli, G.& Russi, Elvio Grazioso& Adamo, V.& Merlano, M. C.. 2011. The Role of p53 and MDM2 in Head and Neck Cancer. ISRN Otolaryngology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-509200
Modern Language Association (MLA)
Denaro, N.…[et al.]. The Role of p53 and MDM2 in Head and Neck Cancer. ISRN Otolaryngology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-509200
American Medical Association (AMA)
Denaro, N.& Lo Nigro, C.& Natoli, G.& Russi, Elvio Grazioso& Adamo, V.& Merlano, M. C.. The Role of p53 and MDM2 in Head and Neck Cancer. ISRN Otolaryngology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-509200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509200