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Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways
Joint Authors
Chen, Xin
Sun, Jiatong
Li, Weiguo
Li, Yan
Jiang, Hong
Lv, Sali
Chen, Huan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs.
So pathways could be considered as targets of small molecules.
A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map.
Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer.
Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases.
These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.
American Psychological Association (APA)
Li, Yan& Li, Weiguo& Chen, Xin& Jiang, Hong& Sun, Jiatong& Chen, Huan…[et al.]. 2014. Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509202
Modern Language Association (MLA)
Li, Yan…[et al.]. Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-509202
American Medical Association (AMA)
Li, Yan& Li, Weiguo& Chen, Xin& Jiang, Hong& Sun, Jiatong& Chen, Huan…[et al.]. Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509202