Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP)
Joint Authors
Griffin, Frank
Tolentino, Brendan
de Lisle, Geoff
Clark, Gary
Mackintosh, Colin
Liggett, Simon
Source
Veterinary Medicine International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Paratuberculosis progresses more quickly in young red deer than in sheep or cattle.
This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge with Mycobacterium avium subsp.
paratuberculosis (MAP).
At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies.
All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50.
Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals.
At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks.
IFN-γ responses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions.
American Psychological Association (APA)
Mackintosh, Colin& Clark, Gary& Tolentino, Brendan& Liggett, Simon& de Lisle, Geoff& Griffin, Frank. 2012. Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP). Veterinary Medicine International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509214
Modern Language Association (MLA)
Mackintosh, Colin…[et al.]. Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP). Veterinary Medicine International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-509214
American Medical Association (AMA)
Mackintosh, Colin& Clark, Gary& Tolentino, Brendan& Liggett, Simon& de Lisle, Geoff& Griffin, Frank. Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge with Mycobacterium avium subsp. paratuberculosis (MAP). Veterinary Medicine International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509214