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Perinatal Programming of Asthma : The Role of Gut Microbiota
Joint Authors
Kozyrskyj, Anita L.
Azad, Meghan B.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism.
In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome.
While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is increasingly apparent that the intestinal microbiota plays an independent and potentially interactive role.
Commensal gut bacteria are essential to immune system development, and exposures disrupting the infant gut microbiota have been linked to asthma.
This paper summarizes the recent findings that implicate caesarean delivery, breastfeeding, perinatal stress, probiotics, and antibiotics as modifiers of infant gut microbiota in the development of asthma.
American Psychological Association (APA)
Azad, Meghan B.& Kozyrskyj, Anita L.. 2011. Perinatal Programming of Asthma : The Role of Gut Microbiota. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-509226
Modern Language Association (MLA)
Azad, Meghan B.& Kozyrskyj, Anita L.. Perinatal Programming of Asthma : The Role of Gut Microbiota. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-509226
American Medical Association (AMA)
Azad, Meghan B.& Kozyrskyj, Anita L.. Perinatal Programming of Asthma : The Role of Gut Microbiota. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-509226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509226