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Clinical Trials of Adult T-Cell LeukaemiaLymphoma Treatment
Joint Authors
Sibon, David
Bazarbachi, Ali
Suarez, Felipe
Hermine, Olivier
Marçais, Ambroise
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive malignancy of mature activated T cells caused by human T-cell lymphotropic virus type I (HTLV-1).
Prognosis is severe because of intrinsic chemoresistance and severe immuosuppression.
Four different subtypes are described with different outcomes, and treatment strategies vary according to the different clinical courses.
Japanese trials show that combinations of chemotherapy can increase the response rates especially in the lymphoma subtype.
However, patients have a high rate of relapse and the outcome remains extremely poor.
Recently, a worldwide meta-analysis demonstrated that the combination of Zidovudine and Interferon-alpha (IFN) is effective in the leukemic subtypes (smoldering, chronic, and acute) and influences favorably the course of the disease.
In order to prevent relapse, clinical trials testing new drugs such as monoclonal antibodies or combinations such as arsenic/IFN are needed.
Finally, allogeneic stem cell transplantation is a feasible option but bears a very high rate of complications.
American Psychological Association (APA)
Marçais, Ambroise& Suarez, Felipe& Sibon, David& Bazarbachi, Ali& Hermine, Olivier. 2012. Clinical Trials of Adult T-Cell LeukaemiaLymphoma Treatment. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509236
Modern Language Association (MLA)
Marçais, Ambroise…[et al.]. Clinical Trials of Adult T-Cell LeukaemiaLymphoma Treatment. Leukemia Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-509236
American Medical Association (AMA)
Marçais, Ambroise& Suarez, Felipe& Sibon, David& Bazarbachi, Ali& Hermine, Olivier. Clinical Trials of Adult T-Cell LeukaemiaLymphoma Treatment. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509236