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Thalassemia and Hemoglobin E in Southern Thai Blood Donors
Joint Authors
Sengking, Warachaya
Horpet, Dararat
Kruachan, Kwanta
Sungyuan, Ubol
Nuinoon, Manit
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thalassemia and hemoglobin E (Hb E) are common in Thailand.
Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia.
Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors.
This study was aimed at determining the frequency of α-thalassemia 1 trait, β-thalassemia trait, and Hb E-related syndromes in Southern Thai blood donors.
One hundred and sixteen voluntary blood donors, Southern Thailand origin, were recruited for thalassemia and Hb E screening by red blood cell indices/dichlorophenolindophenol precipitation test.
β-Thalassemia and Hb E were then identified by high performance liquid chromatography and 4 common α-thalassemia deletions were characterized by a single tube-multiplex gap-polymerase chain reaction.
Overall frequency of hemoglobinopathies was 12.9%, classified as follows: homozygous α-thalassemia 2 (1.7%), heterozygous α-thalassemia 1 (1.7%), heterozygous β-thalassemia without α-thalassemia (0.9%), heterozygous Hb E without α-thalassemia (5.2%), double heterozygotes for Hb E/α-thalassemia 1 (1.7%), homozygous Hb E without α-thalassemia (0.9%), and homozygous Hb E with heterozygous α-thalassemia 2 (0.9%).
The usefulness of thalassemia screening is not only for receiving highly effective red blood cells in the recipients but also for encouraging the control and prevention program of thalassemia in blood donors.
American Psychological Association (APA)
Nuinoon, Manit& Kruachan, Kwanta& Sengking, Warachaya& Horpet, Dararat& Sungyuan, Ubol. 2014. Thalassemia and Hemoglobin E in Southern Thai Blood Donors. Advances in Hematology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509243
Modern Language Association (MLA)
Nuinoon, Manit…[et al.]. Thalassemia and Hemoglobin E in Southern Thai Blood Donors. Advances in Hematology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-509243
American Medical Association (AMA)
Nuinoon, Manit& Kruachan, Kwanta& Sengking, Warachaya& Horpet, Dararat& Sungyuan, Ubol. Thalassemia and Hemoglobin E in Southern Thai Blood Donors. Advances in Hematology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509243