Heterogeneity in Multiple Sclerosis : Scratching the Surface of a Complex Disease

Joint Authors

Disanto, Giulio
De Luca, Gabriele C.
Handunnetthi, Lahiru
Fries, Anastasia
Berlanga, Antonio J.
Para, Andrea E.
Burrell, Amy M.
Morahan, Julia M.
Handel, Adam E.

Source

Autoimmune Diseases

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-09

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system.

Although the etiology and the pathogenesis of MS has been extensively investigated, no single pathway, reliable biomarker, diagnostic test, or specific treatment have yet been identified for all MS patients.

One of the reasons behind this failure is likely to be the wide heterogeneity observed within the MS population.

The clinical course of MS is highly variable and includes several subcategories and variants.

Moreover, apart from the well-established association with the HLA-class II DRB1*15:01 allele, other genetic variants have been shown to vary significantly across different populations and individuals.

Finally both pathological and immunological studies suggest that different pathways may be active in different MS patients.

We conclude that these “MS subtypes” should still be considered as part of the same disease but hypothesize that spatiotemporal effects of genetic and environmental agents differentially influence MS course.

These considerations are extremely relevant, as outcome prediction and personalised medicine represent the central aim of modern research.

American Psychological Association (APA)

Disanto, Giulio& Berlanga, Antonio J.& Handel, Adam E.& Para, Andrea E.& Burrell, Amy M.& Fries, Anastasia…[et al.]. 2010. Heterogeneity in Multiple Sclerosis : Scratching the Surface of a Complex Disease. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-509249

Modern Language Association (MLA)

Disanto, Giulio…[et al.]. Heterogeneity in Multiple Sclerosis : Scratching the Surface of a Complex Disease. Autoimmune Diseases No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-509249

American Medical Association (AMA)

Disanto, Giulio& Berlanga, Antonio J.& Handel, Adam E.& Para, Andrea E.& Burrell, Amy M.& Fries, Anastasia…[et al.]. Heterogeneity in Multiple Sclerosis : Scratching the Surface of a Complex Disease. Autoimmune Diseases. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-509249

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-509249