Effects of Voluntary Running in the Female Mice Lateral Septum on BDNF and Corticotropin-Releasing Factor Receptor 2
Joint Authors
Gustafsson, Sofia
Hilke, Susanne
Liang, Wen
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Voluntary physical activities are known to modulate anxiety and depressive/like behaviors in both animals and humans.
Brain derived neurotrophic factor (BDNF), has been reported to be elevated following exercise.
BDNF, as well as type 2 corticotrophin releasing factor receptor (CRFR) 2, has been shown to mediate anxiety-like behavior.
In the present study we examined the effects of long-term voluntary exercise on the transcripts for BDNF and CRFR2 in the lateral septum (LS) and for CRF in the central amygdala (CeA) in female mice.
Thus, increased activity of CRF in the CeA is associated with anxiety-like behavior.
Quantitative RT-PCR was employed to measure levels of mRNA in punch biopsies from LS and CeA.
In addition, measurements of the concentration of corticosterone and leptin in plasma were employed.
In the LS, we found a three-fold increase of BDNF mRNA (P<0.05) but no significant change in CRFR2 mRNA.
No changes in CRF in the amygdala were observed but we found a decrease in the levels of plasma corticosterone.
Plasma leptin and the weight of perigonadal fat pads were decreased following exercise.
In conclusion, these data show that BDNF gene expression in the LS is influenced by long-term exercise in females but not CRFR2.
American Psychological Association (APA)
Gustafsson, Sofia& Liang, Wen& Hilke, Susanne. 2011. Effects of Voluntary Running in the Female Mice Lateral Septum on BDNF and Corticotropin-Releasing Factor Receptor 2. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509252
Modern Language Association (MLA)
Gustafsson, Sofia…[et al.]. Effects of Voluntary Running in the Female Mice Lateral Septum on BDNF and Corticotropin-Releasing Factor Receptor 2. International Journal of Peptides No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-509252
American Medical Association (AMA)
Gustafsson, Sofia& Liang, Wen& Hilke, Susanne. Effects of Voluntary Running in the Female Mice Lateral Septum on BDNF and Corticotropin-Releasing Factor Receptor 2. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-509252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509252