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The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model
Joint Authors
du Plessis, Jan B.
Bekker, Zanelle
Walubo, Andrew
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
In this study, the role of the immune system in nevirapine- (NVP-) induced subclinical liver injury was investigated by observing for changes of some immune parameters during the initial stages of NVP-induced hepatotoxicity in a rat model.
In the acute phase, two test-groups of 10 Sprague-Dawley rats each were administered with bacterial lipopolysaccharide (LPS) or saline (S) intraperitoneally, followed by oral NVP, after which 5 rats from each group were sacrificed at 6 and 24 hours.
For the chronic phase, two groups of 15 rats each received daily NVP, and on days 7, 14, and 21, five rats from each group were administered with either LPS or S, followed by that day’s NVP dose, and were sacrificed 24 hours later.
NVP caused liver injury up to seven days and progressively increased IL-2 and IFN-γ levels and lymphocyte count over the 21 days.
NVP-induced liver injury was characterized by apoptosis and degeneration changes, while, for LPS, it was cell swelling, leukostasis, and portal inflammation.
Coadministration of NVP and LPS attenuated NVP-induced liver injury.
In conclusion, the immune system is involved in NVP toxicity, and the LPS effects may lay the clue to development of therapeutic strategies against NVP-induced hepatotoxicity.
American Psychological Association (APA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. 2012. The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509279
Modern Language Association (MLA)
Bekker, Zanelle…[et al.]. The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model. ISRN Pharmaceutics No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-509279
American Medical Association (AMA)
Bekker, Zanelle& Walubo, Andrew& du Plessis, Jan B.. The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509279