Dynamic Probing of Nanoparticle Stability In Vivo : A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging
Joint Authors
Lo, Leu-Wei
Tsai, Pi-Ju
Cheng, Shih-Hsun
Yang, Chung-Shi
Ho, Ja-an Annie
Chang, Jerry C.
Huang, Sam Hong-Yi
Jeng, Chien-Chung
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Nanoparticle-mediated drug delivery and controlled release has been a vigorous research area in contemporary nanomedicine.
The in vivo stability of nanoparticle delivered on site is a prerequisite for the design of drug-controlled release by any means.
In this study, the first methodology comprised of microdialysis and optical imaging to assess the liposome stability in vivo is reported.
Macroscopically, we demonstrated the DPPG liposomes with negative surface charge fast accumulated in the rat liver upon their i.v.
administration using optical imaging.
Microscopically, the concurrent analysis of fluorescent molecules leaching from the liposomes, in situ sampled using microdialysis probe, provides the dynamic information of stability of DPPG liposomes locus in quo.
The current combination of in situ microdialysis and optical imaging possesses a great potential for use as a platform technology to evaluate the nanoparticle stability and the bioavailability of drug payload released on targeted site in vivo.
American Psychological Association (APA)
Jeng, Chien-Chung& Cheng, Shih-Hsun& Ho, Ja-an Annie& Huang, Sam Hong-Yi& Chang, Jerry C.& Tsai, Pi-Ju…[et al.]. 2010. Dynamic Probing of Nanoparticle Stability In Vivo : A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-509306
Modern Language Association (MLA)
Jeng, Chien-Chung…[et al.]. Dynamic Probing of Nanoparticle Stability In Vivo : A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging. Journal of Nanomaterials No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-509306
American Medical Association (AMA)
Jeng, Chien-Chung& Cheng, Shih-Hsun& Ho, Ja-an Annie& Huang, Sam Hong-Yi& Chang, Jerry C.& Tsai, Pi-Ju…[et al.]. Dynamic Probing of Nanoparticle Stability In Vivo : A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-509306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509306