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Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells
Joint Authors
Therien, Michael J.
Koch, Cameron J.
Frail, Paul R.
Sood, Nimil
Hammer, Daniel A.
Katz, Joshua S.
Shah, Nikesh N.
Jenkins, Walter T.
Yang, Xiang-Yang
Evans, Sydney M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
Traditional anticancer chemotherapy often displays toxic side effects, poor bioavailability, and a low therapeutic index.
Targeting and controlled release of a chemotherapeutic agent can increase drug bioavailability, mitigate undesirable side effects, and increase the therapeutic index.
Here we report a polymersome-based system to deliver gemcitabine to Panc-1 cells in vitro.
The polymersomes were self-assembled from a biocompatible and completely biodegradable polymer, poly(ethylene oxide)-poly(caprolactone), PEO-PCL.
We showed that we can encapsulate gemcitabine within stable 200 nm vesicles with a 10% loading efficiency.
These vesicles displayed a controlled release of gemcitabine with 60% release after 2 days at physiological pH.
Upon treatment of Panc-1 cells in vitro, vesicles were internalized as verified with fluorescently labeled polymersomes.
Clonogenic assays to determine cell survival were performed by treating Panc-1 cells with varying concentrations of unencapsulated gemcitabine (FreeGem) and polymersome-encapsulated gemcitabine (PolyGem) for 48 hours.
1 μM PolyGem was equivalent in tumor cell toxicity to 1 μM FreeGem, with a one log cell kill observed.
These studies suggest that further investigation on polymersome-based drug formulations is warranted for chemotherapy of pancreatic cancer.
American Psychological Association (APA)
Sood, Nimil& Jenkins, Walter T.& Yang, Xiang-Yang& Shah, Nikesh N.& Katz, Joshua S.& Koch, Cameron J.…[et al.]. 2013. Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509321
Modern Language Association (MLA)
Sood, Nimil…[et al.]. Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells. Journal of Pharmaceutics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-509321
American Medical Association (AMA)
Sood, Nimil& Jenkins, Walter T.& Yang, Xiang-Yang& Shah, Nikesh N.& Katz, Joshua S.& Koch, Cameron J.…[et al.]. Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509321