Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles
Joint Authors
Deramaudt, Therese B.
Takeda, Kenneth
Rondé, Philippe
Hamadi, Abd al-Qadir
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cell adhesion and migration are key determinants in tumor metastasis.
Adherence of tumor cell to the extracellular matrix is mediated via integrin containing focal adhesions (FAs).
Binding of integrins to ECM triggers phosphorylation of two major components of FAs, focal adhesion kinase (FAK) and Src, activating downstream signaling pathway which leads to FA disassembly and cell migration.
In this paper, we analyze how phosphorylation of FAK regulates its trafficking at FAs in living human astrocytoma cells.
Upon pervanadate-induced FAK phosphorylation, phosphorylated FAK appeared highly expressed at newly formed membrane ruffles.
This effect was abolished in presence of the specific Src inhibitor PP2.
Our findings demonstrate that upon phosphorylation, FAK delocalizes from FAs to membrane ruffles.
American Psychological Association (APA)
Hamadi, Abd al-Qadir& Deramaudt, Therese B.& Takeda, Kenneth& Rondé, Philippe. 2010. Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509322
Modern Language Association (MLA)
Hamadi, Abd al-Qadir…[et al.]. Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-509322
American Medical Association (AMA)
Hamadi, Abd al-Qadir& Deramaudt, Therese B.& Takeda, Kenneth& Rondé, Philippe. Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509322