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Dietary Conjugated Linoleic Acid and Hepatic Steatosis : Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression
Joint Authors
Erdman, Richard A.
Vyas, Diwakar
Kadegowda, Anil Kumar G.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To summarize the recent studies on effect of conjugated linoleic acid (CLA) on hepatic steatosis and hepatic and adipose lipid metabolism highlighting the potential regulatory mechanisms.
Methods.
Sixty-four published experiments were summarized in which trans-10, cis-12 CLA was fed either alone or in combination with other CLA isomers to mice, rats, hamsters, and humans were compared.
Summary and Conclusions.
Dietary trans-10, cis-12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species.
Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids (FA) from adipose tissue and the liver's inability to sufficiently increase FA oxidation and export of synthesized triglycerides.
The potential role of liver FA composition, insulin secretion and sensitivity, adipokine, and inflammatory responses are discussed as potential mechanisms behind CLA-induced hepatic steatosis.
American Psychological Association (APA)
Vyas, Diwakar& Kadegowda, Anil Kumar G.& Erdman, Richard A.. 2011. Dietary Conjugated Linoleic Acid and Hepatic Steatosis : Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-509331
Modern Language Association (MLA)
Vyas, Diwakar…[et al.]. Dietary Conjugated Linoleic Acid and Hepatic Steatosis : Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-509331
American Medical Association (AMA)
Vyas, Diwakar& Kadegowda, Anil Kumar G.& Erdman, Richard A.. Dietary Conjugated Linoleic Acid and Hepatic Steatosis : Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression. Journal of Nutrition and Metabolism. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-509331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509331