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Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans : 2006–2010
Joint Authors
Cumba, Luz
Sepúlveda-Torres, Lycely del C.
De La Rosa, Alexandra
Boukli, Nawal
Cubano, Luis A.
Ríos-Olivares, Eddy
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations.
Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system.
Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication.
The average number of HIV mutations was 6.0 in males and 6.1 in females.
Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance.
The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period.
M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed.
American Psychological Association (APA)
Sepúlveda-Torres, Lycely del C.& De La Rosa, Alexandra& Cumba, Luz& Boukli, Nawal& Ríos-Olivares, Eddy& Cubano, Luis A.. 2012. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans : 2006–2010. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509343
Modern Language Association (MLA)
Sepúlveda-Torres, Lycely del C.…[et al.]. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans : 2006–2010. AIDS Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-509343
American Medical Association (AMA)
Sepúlveda-Torres, Lycely del C.& De La Rosa, Alexandra& Cumba, Luz& Boukli, Nawal& Ríos-Olivares, Eddy& Cubano, Luis A.. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans : 2006–2010. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509343