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Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus
Joint Authors
Paiva, Artur
Martinho, António
Inês, Luís
Carvalheiro, Tiago
Pais, Maria L.
Silva, José A. P.
Velada, Isabel
Ribeiro, Andreia
Rodrigues, Ana
Lopes, Ana
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE).
We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA expression, respectively, after cell purification.
The study included 18 SLE patients with active disease (ASLE), 25 with inactive disease (ISLE), and 30 healthy controls (HG).
In purified plasmacytoid DC (pDC) was observed a lower ICOSL mRNA expression in ASLE and an increase in ISLE; similarly, a lower ICOSL mRNA expression in monocytes of ALSE patients was found.
However, a higher ICOSL mRNA expression was observed in ASLE compared to HG in myeloid DCs.
Interestingly, clinical parameters seem to be related with ICOSL mRNA expression.
Regarding the inflammatory activity it was observed in purified monocytes and CD14−/low CD16+ DCs an increase of CCL2, CXCL9, and CXCL10 mRNA expression in ASLE compared to HG.
In myeloid DC no differences were observed regarding chemokines, and IFN-α mRNA expression.
In pDC, a higher IFN-α mRNA expression was observed in ASLE.
Deviations in ICOSL, chemokine, and IFN-α mRNA expression in peripheral blood monocytes and dendritic cells subpopulations in SLE appear to be related to disease activity.
American Psychological Association (APA)
Carvalheiro, Tiago& Rodrigues, Ana& Lopes, Ana& Inês, Luís& Velada, Isabel& Ribeiro, Andreia…[et al.]. 2012. Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-509354
Modern Language Association (MLA)
Carvalheiro, Tiago…[et al.]. Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-509354
American Medical Association (AMA)
Carvalheiro, Tiago& Rodrigues, Ana& Lopes, Ana& Inês, Luís& Velada, Isabel& Ribeiro, Andreia…[et al.]. Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-509354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509354