Effect of Chromium on Antioxidant Potential of Catharanthus roseus Varieties and Production of Their Anticancer Alkaloids : Vincristine and Vinblastine
Joint Authors
Tandon, Pramod Kumar
Rai, Vartika
Khatoon, Sayyada
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Catharanthus roseus (L.) G.
Don, a medicinal plant, has a very important place in the traditional as well as modern pharmaceutical industry.
Two common varieties of this plant rosea and alba are named so because of pink and white coloured flowers, respectively.
This plant comprises of about 130 terpenoid indole alkaloids and two of them, vincristine and vinblastine, are common anticancer drugs.
The effect of chromium (Cr) on enzymatic and non-enzymatic antioxidant components and on secondary metabolites vincristine and vinblastine was studied under pot culture conditions of both varieties of C.
roseus.
Antioxidant responses of these varieties were analyzed under 0, 10, 50, and 100 μM chromium (Cr) level in order to investigate the plant’s protective mechanisms against Cr induced oxidative stress.
The results indicated that Cr affects all the studied parameters and decreases growth performance.
However, vincristine and vinblastine contents were increased under Cr stress.
Results are quite encouraging, as this plant shows good antioxidant potential and increased the level of active constituents under Cr stress.
American Psychological Association (APA)
Rai, Vartika& Tandon, Pramod Kumar& Khatoon, Sayyada. 2014. Effect of Chromium on Antioxidant Potential of Catharanthus roseus Varieties and Production of Their Anticancer Alkaloids : Vincristine and Vinblastine. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509358
Modern Language Association (MLA)
Rai, Vartika…[et al.]. Effect of Chromium on Antioxidant Potential of Catharanthus roseus Varieties and Production of Their Anticancer Alkaloids : Vincristine and Vinblastine. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-509358
American Medical Association (AMA)
Rai, Vartika& Tandon, Pramod Kumar& Khatoon, Sayyada. Effect of Chromium on Antioxidant Potential of Catharanthus roseus Varieties and Production of Their Anticancer Alkaloids : Vincristine and Vinblastine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509358