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CoFactor : Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy
Joint Authors
Makrilia, Nektaria
Saif, Muhammad Wasif
Syrigos, Kostas N.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intracellular reduced folate exists as a “pool” of more than 6 interconvertable forms.
One of these forms, 5,10 methylenetetrahydrofolic acid (CH2THF), is the key one-carbon donor and reduced folate substrate for thymidylate synthase (TS).
This pathway has been an important target for chemotherapy as it provides one of the necessary nucleotide substrates for DNA synthesis.
The fluoropyrimidine 5-fluorouracil (5-FU) exerts its main cytotoxic activity through TS inhibition.
Leucovorin (5-formyltetrahydrofolate; LV) has been used to increase the intracellular reduced folate pools and enhance TS inhibition.
However, it must be metabolized within the cell through multiple intracellular enzymatic steps to form CH2THF.
CoFactor (USAN fotrexorin calcium, (dl)-5,10,-methylenepteroyl-monoglutamate calcium salt) is a reduced folate that potentiates 5-FU cytotoxicity.
According to early clinical trials, when 5-FU is modulated by CoFactor instead of LV, there is greater anti-tumor activity and less toxicity.
This review presents the emerging role of CoFactor in colorectal and nongastrointestinal malignancies.
American Psychological Association (APA)
Saif, Muhammad Wasif& Makrilia, Nektaria& Syrigos, Kostas N.. 2010. CoFactor : Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy. Journal of Oncology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-509374
Modern Language Association (MLA)
Saif, Muhammad Wasif…[et al.]. CoFactor : Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy. Journal of Oncology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-509374
American Medical Association (AMA)
Saif, Muhammad Wasif& Makrilia, Nektaria& Syrigos, Kostas N.. CoFactor : Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-509374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509374