Nuclear Receptor Variants in Liver Disease
Joint Authors
Lammert, Frank
Weber, Susanne N.
Müllenbach, Roman
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This review aims to provide a snapshot of the actual state of knowledge on genetic variants of nuclear receptors (NR) involved in regulating important aspects of liver metabolism.
It recapitulates recent evidence for the application of NR in genetic diagnosis of monogenic (“Mendelian”) liver disease and their use in clinical diagnosis.
Genetic analysis of multifactorial liver diseases such as viral hepatitis or fatty liver disease identifies key players in disease predisposition and progression.
Evidence from these analyses points towards a role of NR polymorphisms in common diseases, linking regulatory networks to complex and variable phenotypes.
The new insights into NR variants also offer perspectives and cautionary advice for their use as handles towards diagnosis and treatment.
American Psychological Association (APA)
Müllenbach, Roman& Weber, Susanne N.& Lammert, Frank. 2012. Nuclear Receptor Variants in Liver Disease. Journal of Lipids،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509404
Modern Language Association (MLA)
Müllenbach, Roman…[et al.]. Nuclear Receptor Variants in Liver Disease. Journal of Lipids No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-509404
American Medical Association (AMA)
Müllenbach, Roman& Weber, Susanne N.& Lammert, Frank. Nuclear Receptor Variants in Liver Disease. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509404