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The Role of Genetic Factors and Kidney and Liver Function in Glycemic Control in Type 2 Diabetes Patients on Long-Term Metformin and Sulphonylurea Cotreatment
Joint Authors
Janež, Andrej
Goričar, Katja
Klen, Jasna
Dolžan, Vita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the influence of genetic polymorphisms of metformin transporters on long-term glycemic control and lipid status in type 2 diabetes patients in the everyday clinical setting.
In total 135 patients treated with combination of metformin and sulphonylurea for at least 6 months were genotyped for SLC22A1 rs628031 and SLC47A1 rs2289669 polymorphisms.
Relatively good blood glucose control with median HbA1c 6.9 (6.4–7.6) % was achieved on prescribed metformin dosage of 2550 (2000–2550) mg per day.
Only 28 (20.7%) patients experienced mild hypoglycemia events, while no severe hypoglycemia events were observed.
Most patients had normal or mildly impaired renal function.
Parameters indicating renal function were not correlated with fasting glucose, HbA1c, or lipid parameters.
Rs628031 and rs2289669 had minor allele frequencies of 0.385 and 0.355, respectively, and were not associated with HbA1c levels.
Rs628031 was marginally associated with risk for hypoglycemia events (P=0.046; OR = 0.51; 95% CI 0.26–0.99), while significant correlation was observed between rs2289669 and total cholesterol levels (P=0.018).
In conclusion, in patients on long-term metformin and sulphonylurea combination treatment, metformin transporters polymorphisms do not play a major role in glycemic control; however, they may influence lipid status.
American Psychological Association (APA)
Klen, Jasna& Goričar, Katja& Janež, Andrej& Dolžan, Vita. 2014. The Role of Genetic Factors and Kidney and Liver Function in Glycemic Control in Type 2 Diabetes Patients on Long-Term Metformin and Sulphonylurea Cotreatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-509406
Modern Language Association (MLA)
Klen, Jasna…[et al.]. The Role of Genetic Factors and Kidney and Liver Function in Glycemic Control in Type 2 Diabetes Patients on Long-Term Metformin and Sulphonylurea Cotreatment. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-509406
American Medical Association (AMA)
Klen, Jasna& Goričar, Katja& Janež, Andrej& Dolžan, Vita. The Role of Genetic Factors and Kidney and Liver Function in Glycemic Control in Type 2 Diabetes Patients on Long-Term Metformin and Sulphonylurea Cotreatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-509406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509406