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Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats
Joint Authors
Cao, Gang
Chen, Xiaocheng
Li, Qinglin
Cai, Hao
Tu, Sicong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats.
Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity.
CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions.
SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions.
These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl4 in rats.
American Psychological Association (APA)
Cao, Gang& Li, Qinglin& Chen, Xiaocheng& Cai, Hao& Tu, Sicong. 2014. Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509407
Modern Language Association (MLA)
Cao, Gang…[et al.]. Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-509407
American Medical Association (AMA)
Cao, Gang& Li, Qinglin& Chen, Xiaocheng& Cai, Hao& Tu, Sicong. Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509407