The Fur Transcription Regulator and Fur-Regulated Genes in Clostridium botulinum A ATCC 3502
Joint Authors
Zhang, Weibin
Ma, Junhua
Liu, Peipei
Zang, Chengyuan
Song, Yingying
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clostridium botulinum is a spore-forming bacterium that can produce a very powerful neurotoxin that causes botulism.
In this study, we have investigated the Fur transcription regulators in Clostridium botulinum and Fur-regulated genes in Clostridium botulinum A ATCC 3502.
We found that gene loss may be the main cause leading to the different numbers of Fur transcription regulators in different Clostridium botulinum strains.
Meanwhile, 46 operons were found to be regulated by the Fur transcription regulator in Clostridium botulinum A ATCC 3502, involved in several functional classifications, including iron acquisition, iron utilization, iron transport, and transcription regulator.
Under an iron-restricted medium, we experimentally found that a Fur transcription regulator (CBO1372) and two operons (DedA, CBO2610–CBO2614 and ABC transporter, CBO0845–CBO0847) are shown to be differentially expressed in Clostridium botulinum A ATCC 3502.
This study has provided-us novel insights into the diversity of Fur transcription regulators in different Clostridium botulinum strains and diversity of Fur-targeted genes, as well as a better understanding of the dynamic changes in iron restriction occurring in response to this stress.
American Psychological Association (APA)
Zhang, Weibin& Ma, Junhua& Zang, Chengyuan& Song, Yingying& Liu, Peipei. 2011. The Fur Transcription Regulator and Fur-Regulated Genes in Clostridium botulinum A ATCC 3502. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-509412
Modern Language Association (MLA)
Zhang, Weibin…[et al.]. The Fur Transcription Regulator and Fur-Regulated Genes in Clostridium botulinum A ATCC 3502. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-509412
American Medical Association (AMA)
Zhang, Weibin& Ma, Junhua& Zang, Chengyuan& Song, Yingying& Liu, Peipei. The Fur Transcription Regulator and Fur-Regulated Genes in Clostridium botulinum A ATCC 3502. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-509412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509412