Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin
Joint Authors
Heim, Sverre
Hall, Kirsten Sundby
Bjerkehagen, Bodil
Beiske, Klaus
Heldal, Dag
Fløisand, Yngvar
Delabie, Jan
Bruland, Øyvind Sverre
Tierens, Anne
Revheim, Mona-Elisabeth
Tjønnfjord, Geir Erland
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia.
These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromosome 12p, i(12p), in cells from both the solid tumor and the leukemia, and thus are now known to represent different manifestations of the same clonal process.
We treated a young female patient with a malignant phyllodes tumor followed by an acute megakaryoblastic leukemia and found several of the same marker chromosomes by karyotype analysis of cells from both the tumor and the leukemia implying a common clonal origin of the two.
To the best of our knowledge, this has not been demonstrated in phyllodes tumors before, but indicates that the same type of leukemization may occur of this tumor as has been described in mediastinal GCT.
American Psychological Association (APA)
Fløisand, Yngvar& Beiske, Klaus& Tjønnfjord, Geir Erland& Heldal, Dag& Bjerkehagen, Bodil& Revheim, Mona-Elisabeth…[et al.]. 2013. Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-509415
Modern Language Association (MLA)
Fløisand, Yngvar…[et al.]. Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin. Case Reports in Hematology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-509415
American Medical Association (AMA)
Fløisand, Yngvar& Beiske, Klaus& Tjønnfjord, Geir Erland& Heldal, Dag& Bjerkehagen, Bodil& Revheim, Mona-Elisabeth…[et al.]. Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-509415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509415