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Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors
Joint Authors
Williams, Brent W.
Koonce, Nathan A.
Asur, Rajalakshmi
Bischof, John C.
Song, Chang W.
Griffin, Robert J.
Upreti, Meenakshi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Our previous studies demonstrated arsenic trioxide- (ATO-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors.
These results suggested that a trimodality approach of radiation, ATO, and local hyperthermia may have potent therapeutic efficacy against solid tumors.
Here, we report the antitumor effect of hypofractionated radiation followed by ATO administration and local 42.5 °C hyperthermia and the effects of cisplatin and thermoradiotherapy.
We found that the therapeutic efficacy of ATO-based thermoradiotherapy was equal or greater than that of cisplatin-based thermoradiotherapy, and marked evidence of in vivo apoptosis and tumor necrosis were observed in ATO-treated tumors.
We conclude that ATO-based thermoradiotherapy is a powerful means to control tumor growth by using vascular disruption to augment the effects of thermal and radiation therapy.
American Psychological Association (APA)
Griffin, Robert J.& Williams, Brent W.& Koonce, Nathan A.& Bischof, John C.& Song, Chang W.& Asur, Rajalakshmi…[et al.]. 2012. Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-509432
Modern Language Association (MLA)
Griffin, Robert J.…[et al.]. Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-509432
American Medical Association (AMA)
Griffin, Robert J.& Williams, Brent W.& Koonce, Nathan A.& Bischof, John C.& Song, Chang W.& Asur, Rajalakshmi…[et al.]. Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-509432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509432