Role of Oxidative Stress in Transformation Induced by Metal Mixture
Joint Authors
Emilio, Rojas
Mahara, Valverde
Martín, Silva-Aguilar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Metals are ubiquitous pollutants present as mixtures.
In particular, mixture of arsenic-cadmium-lead is among the leading toxic agents detected in the environment.
These metals have carcinogenic and cell-transforming potential.
In this study, we used a two step cell transformation model, to determine the role of oxidative stress in transformation induced by a mixture of arsenic-cadmium-lead.
Oxidative damage and antioxidant response were determined.
Metal mixture treatment induces the increase of damage markers and the antioxidant response.
Loss of cell viability and increased transforming potential were observed during the promotion phase.
This finding correlated significantly with generation of reactive oxygen species.
Cotreatment with N-acetyl-cysteine induces effect on the transforming capacity; while a diminution was found in initiation, in promotion phase a total block of the transforming capacity was observed.
Our results suggest that oxidative stress generated by metal mixture plays an important role only in promotion phase promoting transforming capacity.
American Psychological Association (APA)
Martín, Silva-Aguilar& Emilio, Rojas& Mahara, Valverde. 2011. Role of Oxidative Stress in Transformation Induced by Metal Mixture. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-509458
Modern Language Association (MLA)
Martín, Silva-Aguilar…[et al.]. Role of Oxidative Stress in Transformation Induced by Metal Mixture. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-509458
American Medical Association (AMA)
Martín, Silva-Aguilar& Emilio, Rojas& Mahara, Valverde. Role of Oxidative Stress in Transformation Induced by Metal Mixture. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-509458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509458