The Actin-Bundling Protein L-Plastin : A Critical Regulator of Immune Cell Function
Author
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia.
While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the requirement for L-plastin in multiple functions critical for immunity, such as antigen receptor signaling, adhesion, and motility, has only recently become clear.
L-plastin has been identified as an important component in cellular processes critical for neutrophil, macrophage, osteoclast, eosinophil, and T- and B-lymphocyte biology.
Following a brief description of the structure and function of L-plastin, the regulation of immune cell functions by L-plastin will be reviewed in detail.
American Psychological Association (APA)
Morley, Sharon Celeste. 2011. The Actin-Bundling Protein L-Plastin : A Critical Regulator of Immune Cell Function. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-509460
Modern Language Association (MLA)
Morley, Sharon Celeste. The Actin-Bundling Protein L-Plastin : A Critical Regulator of Immune Cell Function. International Journal of Cell Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-509460
American Medical Association (AMA)
Morley, Sharon Celeste. The Actin-Bundling Protein L-Plastin : A Critical Regulator of Immune Cell Function. International Journal of Cell Biology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-509460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509460