Vitreous Mediators in Retinal Hypoxic Diseases
Joint Authors
Romano, Mario R.
Semeraro, Francesco
Bamonte, Giulio
Cifariello, Francesco
dell'Omo, Roberto
Costagliola, Ciro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The causes of retinal hypoxia are many and varied.
Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines.
Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biological process, including cell proliferation, inflammation, immunity, migration, fibrosis, tissue repair, and angiogenesis.
Cytokines and chemokines are multifunctional mediators that can direct the recruitment of leukocytes to sites of inflammation, promote the process, enhance immune responses, and promote stem cell survival, development, and homeostasis.
The modern particle-based flow cytometric analysis is more direct, stable and sensitive than the colorimetric readout of the conventional ELISA but, similar to ELISA, is influenced by vitreous hemorrhage, disruption of the blood-retina barrier, and high serum levels of a specific protein.
Finding patterns in the expression of inflammatory cytokines specific to a particular disease can substantially contribute to the understanding of its basic mechanism and to the development of a targeted therapy.
American Psychological Association (APA)
dell'Omo, Roberto& Semeraro, Francesco& Bamonte, Giulio& Cifariello, Francesco& Romano, Mario R.& Costagliola, Ciro. 2013. Vitreous Mediators in Retinal Hypoxic Diseases. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-509470
Modern Language Association (MLA)
dell'Omo, Roberto…[et al.]. Vitreous Mediators in Retinal Hypoxic Diseases. Mediators of Inflammation No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-509470
American Medical Association (AMA)
dell'Omo, Roberto& Semeraro, Francesco& Bamonte, Giulio& Cifariello, Francesco& Romano, Mario R.& Costagliola, Ciro. Vitreous Mediators in Retinal Hypoxic Diseases. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-509470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509470