Evaluation of Incidence and Clinical Features of Antibody-Associated Autoimmune Encephalitis Mimicking Dementia
Joint Authors
Gürvit, Hakan
İsmail Küçükali, Cem
Tüzün, Erdem
Üçok, Alp
Ünübol, Hüseyin
Yalçınkaya, Nazlı
Haytural, Hazal
Çakır, Sibel
Hanagasi, Hasmet A.
Ulusoy, Canan
Bilgiç, Başar
Çoban, Arzu
Turan, Selin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Anti-neuronal autoimmunity may cause cognitive impairment that meets the criteria for dementia.
Objective.
Our aim was to detect the incidence and clinical features of autoimmune encephalitis imitating clinical findings of primary dementia disorders and to delineate the validity of anti-neuronal antibody screening in dementia patients.
Methods.
Fifty consecutive patients fulfilling the clinical criteria for primary dementia, 130 control patients, and 50 healthy controls were included.
Their sera were investigated for several ion channel and glutamic acid decarboxylase (GAD) antibodies by a cell-based assay, radioimmunoassay, and ELISA, as required.
Results.
Sixteen patients satisfying dementia criteria had atypical findings or findings suggestive of autoimmune encephalitis.
N-methyl-D-aspartate receptor (NMDAR) antibody was detected in a patient with dementia, Parkinsonism, and REM sleep behavior disorder (RBD) fulfilling the criteria for dementia with Lewy bodies (DLB).
One control patient with bipolar disease displayed low anti-GAD antibody levels.
Conclusions.
Our study showed for the first time the presence of parkinsonism and RBD in an anti-NMDAR encephalitis patient mimicking DLB.
Although autoimmune encephalitis patients may occasionally present with cognitive decline, most dementia patients do not exhibit anti-neuronal antibodies, suggesting that routine analysis of these antibodies in dementia is not mandatory, even though they display atypical features.
American Psychological Association (APA)
Çoban, Arzu& İsmail Küçükali, Cem& Bilgiç, Başar& Yalçınkaya, Nazlı& Haytural, Hazal& Ulusoy, Canan…[et al.]. 2014. Evaluation of Incidence and Clinical Features of Antibody-Associated Autoimmune Encephalitis Mimicking Dementia. Behavioural Neurology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-509479
Modern Language Association (MLA)
Çoban, Arzu…[et al.]. Evaluation of Incidence and Clinical Features of Antibody-Associated Autoimmune Encephalitis Mimicking Dementia. Behavioural Neurology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-509479
American Medical Association (AMA)
Çoban, Arzu& İsmail Küçükali, Cem& Bilgiç, Başar& Yalçınkaya, Nazlı& Haytural, Hazal& Ulusoy, Canan…[et al.]. Evaluation of Incidence and Clinical Features of Antibody-Associated Autoimmune Encephalitis Mimicking Dementia. Behavioural Neurology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-509479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509479