Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats
Joint Authors
Ashafa, Anofi Omotayo Tom
Yakubu, Musa Toyin
Kazeem, Mutiu Idowu
Akanji, Musbau Adewunmi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the hepatoprotective effects of polyphenols from Zingiber officinale on streptozotocin-induced diabetic rats by assessing liver antioxidant enzymes, carbohydrate-metabolizing enzymes and liver function indices.
Initial oral glucose tolerance test was conducted using 125 mg/kg, 250 mg/kg, and 500 mg/kg body weight of both free and bound polyphenols from Z.
officinale.
28 day daily oral administration of 500 mg/kg body weight of free and bound polyphenols from Z.
officinale to streptozotocin-induced (50 mg/kg) diabetic rats significantly reduced (P<0.05) the fasting blood glucose compared to control groups.
There was significant increase (P<0.05) in the antioxidant enzymes activities in the animals treated with both polyphenols.
Similarly, the polyphenols normalised the activities of some carbohydrate metabolic enzymes (hexokinase and phosphofructokinase) in the liver of the rats treated with it and significantly reduced (P<0.05) the activities of liver function enzymes.
The results from the present study have shown that both free and bound polyphenols from Z.
officinale especially the free polyphenol could ameliorate liver disorders caused by diabetes mellitus in rats.
This further validates the use of this species as medicinal herb and spice by the larger population of Nigerians.
American Psychological Association (APA)
Kazeem, Mutiu Idowu& Akanji, Musbau Adewunmi& Yakubu, Musa Toyin& Ashafa, Anofi Omotayo Tom. 2013. Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509494
Modern Language Association (MLA)
Kazeem, Mutiu Idowu…[et al.]. Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-509494
American Medical Association (AMA)
Kazeem, Mutiu Idowu& Akanji, Musbau Adewunmi& Yakubu, Musa Toyin& Ashafa, Anofi Omotayo Tom. Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509494