Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders
Joint Authors
Ashwood, Paul
Careaga, Milo
Van de Water, Judy
Hansen, Robin L.
Hertz-Piccotto, Irva
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Autism spectrum disorders (ASD) are characterized by impairments in communication, social interactions, and repetitive behaviors.
While the etiology of ASD is complex and likely involves the interplay of genetic and environmental factors, growing evidence suggests that immune dysfunction and the presence of autoimmune responses including autoantibodies may play a role in ASD.
Anti-phospholipid antibodies are believed to occur from both genetic and environmental factors and have been linked to a number of neuropsychiatric symptoms such as cognitive impairments, anxiety, and repetitive behaviors.
In the current study, we investigated whether there were elevated levels of anti-phospholipid antibodies in a cross-sectional analysis of plasma of young children with ASD compared to age-matched typically developing (TD) controls and children with developmental delays (DD) other than ASD.
We found that levels of anti-cardiolipin, β2-glycoprotein 1, and anti-phosphoserine antibodies were elevated in children with ASD compared with age-matched TD and DD controls.
Further, the increase in antibody levels was associated with more impaired behaviors reported by parents.
This study provides the first evidence for elevated production of anti-phospholipid antibodies in young children with ASD and provides a unique avenue for future research into determining possible pathogenic mechanisms that may underlie some cases of ASD.
American Psychological Association (APA)
Careaga, Milo& Hansen, Robin L.& Hertz-Piccotto, Irva& Van de Water, Judy& Ashwood, Paul. 2013. Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509496
Modern Language Association (MLA)
Careaga, Milo…[et al.]. Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-509496
American Medical Association (AMA)
Careaga, Milo& Hansen, Robin L.& Hertz-Piccotto, Irva& Van de Water, Judy& Ashwood, Paul. Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-509496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509496